New entries are listed at the top of the list, latest added 27 Apr 2000

Department of Physics and Astronomy: University of Leeds

Lectureships/ Senior Lectureship/Readership

The Department of Physics and Astronomy at the University of Leeds plans to make two academic appointments in the areas of Condensed Matter Physics and of Molecular Physics or Biophysics. Both appointees will have research records commensurate with a grade 5 RAE research rating. The posts may be filled at lectureship level (A or B) but for a suitably qualified candidate one of the appointments may be made at senior lectureship or readership level.

One post will be in the Condensed Matter Group which is to be headed by Professor R Cywinski when he takes up his Chair on 1 September 2000. The interests of the group are wide ranging and encompass the magnetic and superconducting properties of alloys, compounds and nanoscale structures. There is a wide range of in-house facilities for the preparation of thin films, including MBE and sputtered thin films and crystalline and amorphous alloys. The group profits from a wide range of national and international collaborations and has strong links with major neutron and muon beam facilities. The research activities of the successful applicant must complement and extend the existing research profile of the Group. The other post will be in Molecular Physics or Biophysics in the group headed by Professor Batchelder. Research in the Group is currently focused on studies of self-organising films and nanoparticles, solid-supported bilayers, wetting and wetting transitions, polymer structure, protein structure and folding, and biomolecular interactions. Techniques used and developed in the Group include Raman microscopy and SNOM; FTIR, UV-Vis and fluorescence spectroscopy; ps and ns time-resolved fluorescence spectroscopy; single molecule spectroscopy; AFM and STM and ellipsometry. In the area of theoretical macromolecular physics and biophysics, collaborations are currently growing with the research group in Polymers and Complex Fluids.

For general enquiries about the post, contact Professor Alan Watson ([email protected]). Specific enquiries about the first post may be made to Professor R Cywinski ([email protected]), Professor G J Morgan ([email protected]) or Dr B J Hickey ([email protected]). For enquiries about the second post please contact Professor D N Batchelder ([email protected]), Dr Steve Evans ([email protected]) or Dr Alastair Smith ([email protected]). The closing date for applications is 30 April 2000 and it is hoped that the appointees will take up their posts on 1 September 2000 or as soon as possible thereafter.


POSTDOCTORAL POSITION

A postdoctoral position is now available in the area of materials science for engineering applications using diffraction techniques, primarily neutron. The position is in conjunction with the Department of Materials Science of the State University of New York (Stony Brook) with which NIST has a cooperative research agreement; the neutron research would be conducted at the NIST Center for Neutron Research (NCNR). A main focus of the NCNR/SUNY collaboration is in the area of texture and residual stress in coatings, and their effect on performance and durability. In addition, theoretical efforts are underway in the understanding of elastic properties of complex systems such as coatings, which are tested by neutron measurements. Other recent studies have included residual stress determinations for weldments, railroad rails, and automobile components.

The NCNR is a very complete neutron facility, with a cold source and guide hall. All instruments are available to all staff members. In addition, NIST's Materials Science and Engineering Lab, of which the NCNR is a part, is a member of the UNICAT collaboration at the Advanced Photon Source at Argonne National Lab. As such, NCNR scientists have access to UNICAT instruments.

Educational requirements are a Ph.D. in Condensed Matter Physics, Materials Science, or related field. Experience in neutron or x-ray diffraction stress or texture measurement, demonstrated interpersonal, written, and verbal skills, and the ability to work in a team environment are also prerequisite. Experience in finite element calculations would be advantageous. The successful candidate will have opportunities to pursue existing programs and to initiate new projects. He or she will join a group of one staff member and a postdoctoral research associate currently working in the area of neutron diffraction stress measurement. Annual starting salaries range from $43,000 to $48,000, plus a generous, comprehensive benefits package.

Expressions of interest should be sent with a resume to:


Dr. Henry Prask,Center for Neutron Research,M.S. 8560
National Institute of Standards and Technology,100 Bureau Drive
Gaithersburg, MD 20899, USA

Tel: +1 301-975-6226; FAX: +1 301-921-9847 e-mail: [email protected]

or

Professor Sanjay Sampath, Center for Thermal Spray Research, Department of Materials Science and Engineering, State University of New York, 105 Old Engineering Bldg., Stony Brook, NY 11794-2275, USA

Tel: +1 631-632-9512; FAX: +1 631-632-7878 e-mail: [email protected]


Post-doctoral positions, Chicago
Protein Structure and Function

University of Illinois at Chicago

Applications are invited for postdoctoral positions in structural biology available immediately at UIC. The positions require a Ph.D. in structural biology, biochemistry or a closely related field. The ideal candidates will have interests in protein structure and function, and will have either extensive experience in protein biochemistry, with a strong desire to learn macromolecular X-ray crystallography, or experience in crystallography with a desire to learn protein biochemistry.

The following projects are available:

  1. Structure-function relationships of kinases important for prodrug activation, with emphasis on structure based enzyme design (Nat. Struc. Biol. (1997) 4, 601-604; Nat. Med. (1997) 3, 922-924).
  2. Protein-protein interactions of neuronal proteins.
The laboratories are located in a new state-of-the-art building that houses our Macromolecular Crystallography Center. The center and our 25 minute proximity to the Advanced Photon Source make UIC an excellent environment for x-ray crystallographic studies. UIC, the largest University in the Chicago area and the largest medical school in the nation, is located near downtown Chicago, a city with great cultural and scenic offerings. For more information, please visit our Web site at: http://www.uic.edu/~lavie/

Informal inquiries can be made via E-mail to: [email protected]
The University of Illinois at Chicago is an Affirmative Action/Equal Opportunity Employer.


THE OPEN UNIVERSITY INVESTING IN RESEARCH
DEPARTMENT OF MATERIALS ENGINEERING, FACULTY OF TECHNOLOGY

RESEARCH FELLOW IN THE ENGINEERING USE OF NEUTRONS

(Temporary three year post)

An excellent research opportunity is available for a post-doctoral candidate with a background in Engineering, Physics or Materials.

The post is a three-year appointment, funded by the EPSRC as part of a 2.5 million pound program to design and build ENGIN-X a next-generation engineering stress neutron diffractometer at ISIS, the world's premiere spallation neutron source which is located at the Rutherford Appleton Laboratory near Didcot in Oxfordshire. This instrument is expected to provide 10 times the performance of presently available machines. The primary responsibility of this position will be to develop the technique of pulsed neutron strain scanning to enable the true potential of ENGIN-X to be realised. The post will be based within the Materials Engineering Department of the Open University.

The appointment will be made on the Research salary scale within the salary range �16,286 - �24,479 p.a. (under review) depending on qualifications and experience. Experience of neutron strain scanning and/or familiarity with diffraction-based crystallography and/or Reitveld methods would be desirable. Appointment as a Research Fellow requires a PhD or three years equivalent in quality of achievement.

Informal enquiries about the post can be made to Dr Lyndon Edwards on 01908 653385 email: [email protected] or Dr Michael Fitzpatrick on 01908 653100.

Further particulars, an application form and access details for disabled applicants are available from the RecruitmentCo-ordinator, email: [email protected], or telephone 01908 653941. There is a 24-hour answering service on 01908 654144. Further particulars are also available from www-tec.open.ac.uk/deanery/recruit.html.

Closing date for applications: 4 May 2000

Disabled applicants whose skills and experience meet the requirements of the job will be interviewed. Please let us know ifyou need your copy of the further particulars in large print, on computer disk, or on audio cassette tape. Hearing impaired persons may make enquiries on Milton Keynes (01908) 654901 (Minicom answerphone).

Equal Opportunity is University Policy.

The University offers a wide range of jobs with excellent training and career development opportunities. We actively promote equal opportunities in education and employment and welcome applications from all sections of the community.


Forward from daphnet and : (MCFA is the Marie Curie Fellowship Association)

Improving Human Research Potential

Eight Post Doctoral Positions are available in chemistry, physics, enzymology, protein crystallography, molecular biology and genetics for between 26 and 36 months from April 2000.

These positions are available in the laboratories of Prof. S Fetzner (University of Oldenburg, Germany), Dr E Garattini (Istituto di Ricerche Farmacologiche, Italy), Prof. R Huber (Max-Planck-Institut fur Biochemie, Germany), Prof. J H�ttermann (Saarland University, Germany), Dr DJ Lowe (John Innes Centre, UK), Prof. M J Rom�o (Universidade Nova de Lisboa, Portugal), Prof. C Scazzocchio (University of Paris-Sud, France) and Dr AT Smith (University of Sussex, UK). The project is a multidisciplinary approach to the structure and the function of molybdenum-containing enzymes.

The Young Researchers employed must be aged 35 years or less at the time of their appointment (with allowances for childcare and military or civil service). They must be a national of a Member State of the European Community, or of an Associated State, or have resided in the Community for at least five years prior to their appointment. They must not be a national of the state in which the participating laboratory in which they are employed is situated, and must not have carried out normal activities in that state for more than 12 of the 24 months prior to appointment.

All employers in the network have policies promoting equal opportunities.

For further details about these positions please see the web site:

http://www.jic.bbsrc.ac.uk/staff/david-lowe/jobs.htm


JOIN THE OU AS IT BUILDS ON 30 YEARS OF SUCCESS

Senior Lectureship and Lectureship in Applied Mathematics

The Open University invites applications for one Senior Lectureship and one Lectureship in Applied Mathematics. These posts are part of a major commitment to strengthen both research and teaching in Applied Mathematics, which includes the appointment of Professor Michael Wilkinson to a Chair in Applied Mathematics.

You should have a strong record of independent research, and a commitment to maintaining a lively research environment at the Open University. Applications are welcome from scholars with interests in any aspect of Applied Mathematics or Theoretical Physics, but preference will be given to candidates whose interests will stimulate interactions with other members of staff. Applications from candidates with interests in quantum mechanics, theoretical condensed matter physics, non-linear dynamics, statistical physics and fluid dynamics are especially welcome. Generous study leave provisions guarantee opportunities for research.

The Open University teaches highly motivated students who usually study part-time in their own homes. The posts involve preparing teaching materials for use by students and locally-based tutors, using a wide range of learning technologies. Ability to work as part of a team and enthusiasm for good teaching are essential. Candidates should show evidence of teaching and administrative ability which is commensurate with their experience.

The posts are based in Milton Keynes. Confidential informal enquiries may be made to Professor Michael Wilkinson (email: [email protected]) or Professor David Brannan ([email protected]). For further information on these posts and an application form, please contact The Recruitment Secretary, Faculty of Mathematics and Computing, The Open University, Walton Hall, Milton Keynes MK7 6AA, UK (Tel: +44 (0)1908-654161; email: [email protected]).

The Lecturer salary will be between oe17,238 and oe30,065 - or exceptionally up to oe33,593 - according to experience and qualifications. The Senior Lecturer salary will be between oe31,563 and oe35,560, according to experience and qualifications.

The closing date for applications is Friday 5th May 2000.

Disabled applicants whose skills and experience meet the requirements of the job will be interviewed. Please let us know if you need your copy of the further particulars in large print, on computer disk, or on audio-cassette tape. Hearing impaired persons may make enquiries on Milton Keynes (01908) 654901 (Minicom answerphone). Equal Opportunity is University Policy. http://watt.open.ac.uk/personnel/emp/pr.htm


Please will you pass this information to anyone in your Department who might be interested in this position?

[Women applicants would be particularly welcome - Mary Masson email: [email protected] ]

The University of Aberdeen
Chair in the Chemistry of Materials

The University seeks to appoint a dynamic individual to an established Chair which forms part of an investment programme for Chemistry at Aberdeen. The Chair will be held in any field relating to the chemistry of inorganic, organic or biological materials. The Department of Chemistry has long-established interests in materials research (e.g. inorganic solids, glasses, cements, ceramics; polymers. liquid crystals, polymer electrolytes, bone chemistry) and equipment levels are generally of a high standard. Candidates should have an international reputation for innovative research and publication, a demonstrated ability to raise research funding, and leadership skills.

Much of the Department's future research activity will be in areas at the boundaries of Chemistry with Engineering, Geology, Medicine and Biology. Applications from those with a commitment to interdisciplinary research and a strong interest in these areas will be particularly welcome. The new professor will have a key leadership role in enhancing and expanding the Department's research profile, including having a major influence in appointing a number of staff over the next five years.

Confidential and informal enquiries may be directed to: Dr Geoff McQuillan. Head of Department
(Tel: + 44 (0)1224 272944. fax: 272921, email: [email protected]).

Application forms and further particulars are available from:
Human Resources, University of Aberdeen, King's College. Aberdeen. AB24 3FX

(Tel: +44 (0)1224 272727, email: [email protected]) quoting reference number FCM005A.

A 24-hour answering service is in operation.

Closing date: 12 May 2000
An Equal Opportunities Employer
See also http://www.abdn.ac.uk/chemistry/


Postdoc position in physics

The Hahn-Meitner-Institut invites applications for a post-doctoral position in the area of the structure of condensed matter.

The Hahn-Meitner-Institute is a German National Laboratory and a member of the Hermann von Helmholtz Association of National Research Centres and has about 850 employees. It hosts the Berlin Neutron Scattering Centre (BENSC) (http://www.hmi.de/bensc/), a user facility open to scientists from all over the world. To probe the structure and dynamics of solids and liquids, BENSC provides scientists with state-of-the-art neutron scattering equipment. Successful candidates should be interested in experimental physics, collaborating with other scientists, and instrument development.

Postdoctoral position physicist
(The position is available as of 15 June 2000 and tenable for 3 years)

This position is open to post-doctoral candidates who are looking for an entry position in research. The responsibilities of the successful candidate will include studies with ultracold neutrons (UCN) stored in suprafluid He4 as well as the development and testing of magnetic focussing techniques for small angle scattering instruments.

Currently experiments on the neutron lifetime (important for big bang nucleosynthesis and tests of the standard model) and the search for the existence of the neutron electric dipole moment (edm) have been performed with UCN. This work is done in an international collaboration (Harvard University, Los Alamos, National Inst. of Science and Technology) to develop and apply this technique.

Technical advances in magnetic neutron beam focussing techniques will open up new possibilities for the study of condensed matter on the mesoscopic lengthscale.

The candidate should have experience with designing and constructing apparatus, preferably, but not necessarily in one of the related fields: neutron physics, particle physics, low temperatures.

For further details about the post contact: Dr. R. Golub (+49(30)8062-2829, e-mail: [email protected])
or Prof. F. Mezei (+49(30)8062-2322).

Applicants should send a letter of application, CV and a list of publications to: Dr. R. Golub, Hahn-Meitner-Institut, Dept. SF1, Glienicker Str. 100, D-14109 Berlin, Germany

before 15 May 2000.


Loughborough University

Lecturer in Inorganic Chemistry

Department of Chemistry
 

Salary �17,238 - �22,579 per annum

 Required as part of a strategic initiative for a major enhancement of its research profile and teaching strength the Department of Chemistry wishes to appoint a Lecturer in Inorganic chemistry.

 Applications for the post are invited from individuals with research interests in any area of the discipline. Experience in X-ray structural analysis, and willingness to participate in the provision of a departmental service would be an advantage.

 Informal contact is welcomed and should be addressed to:
Dr P F Kelly, Tel: 01509 222578 or email: [email protected]

or Professor Philip Page, Tel 01509 222580 or email: [email protected]

Also see http://www.lboro.ac.uk

 Further details (also available at http://www.lboro.ac.uk/admin/personnel/chemlect.html

and an application form are available from Personnel Services, Loughborough University, Loughborough, Leics, LE11 3TU.
Tel: 01509 222173 (24 hours or email: [email protected]

Quote reference CM/183/W   Closing date 19th May 2000


INSTRUMENT SCIENTIST FOR ENGINEERING APPLICATIONS

Rutherford Appleton Laboratory, Oxfordshire

Fixed Term (3 years)

Neutron strain scanning is a rapidly developing technique for the non-destructive measurement of stress and strain. A second generation strain scanning instrument, ENGIN-X, is presently under construction at ISIS, the world's leading pulsed neutron source. This will bring an order of magnitude improvement in performance over the existing ENGIN. There is therefore a requirement for an instrument scientist to join the existing engineering team.

The post holder will be expected to take an active part in developing the engineering field at ISIS. In particular, they will spend time both as instrument scientist for ENGIN, and assisting in developing new methods of data analysis and new neutron scattering techniques of interest to engineers and metallurgists, for use on ENGIN-X. In addition to helping support the engineering instruments, the post holder would also be expected to develop their own research program, and assist in commercial research where relevant.

Candidates should have a first degree in Physics, Engineering, Metallurgy or Materials Science and a relevant PhD or equivalent experience. Familiarity with the neutron strain scanning technique is essential, and a general understanding of other neutron scattering techniques of use to metallurgists and engineers would also be an advantage. The ideal candidate will also have experience of data analysis methods and be able to write data analysis computer programs themselves when required. An ability to understand the broad range of problems faced by commercial users is necessary, as is an ability to communicate well with research managers in industry.

The salary range is between �18,620 and �24,000, depending on experience. A non-contributory pension scheme and a generous leave allowance are offered. For further details about the post, please contact Dr MR Daymond, telephone +44 (0)1235 445414, or e-mail [email protected]

Application forms can be obtained from:
Operations Group, HR Division, Rutherford Appleton Laboratory, Chilton, Didcot, Oxfordshire, OX11 0QX.
Tel: (01235) 445435 (answerphone) quoting reference VN1925, or e-mail [email protected].
More information about CCLRC and application forms are available from CCLRC's World Wide Web pages at http://www.cclrc.ac.uk

All applications must be returned by 25 May 2000.

The CCLRC is committed to Equal Opportunities and to achieving the Investors In People standard. A no smoking policy is in operation.


POSTDOCTORAL OPPORTUNITIES

Howard Hughes Medical Institute and Biomolecular Structure Center
University of Washington, Seattle, USA

In the near future several postdoctoral fellowships are available in our laboratory to work on a number of medically relevant structural biology projects. The goals of these studies are to unravel mechanisms of action of proteins and at the same time use the structural information obtained for the development of potentially useful therapeutic compounds. The projects are all embedded in exciting structure-based drug design collaborative networks.

Most of the projects are aimed to combat major infectious diseases, while one is also of major importance for cancer. A brief description of projects is as follows:

  1. Structural investigations of the biogenesis of unique organelles, called glycosomes, in Trypanosomatids which are protozoa responsible for several of the most important infectious diseases world wide. The glycosomal matrix proteins are all synthesized in the cytoplasm after which they are transported into the glycosome via a most unusual and interesting yet far from completely understood import mechanism. This process somehow involves almost two dozen different proteins called "peroxins". The goal of the project is to unravel the structures of the proteins crucial for this import process, to see how they interact with the "cargo proteins" and with each other during the translocation of proteins from the cytoplasm into the glycosome. Structure-based inhibitor design projects, aiming at discovering selective inhibitors of this import process, will be initiated immediately once crystal structures have been elucidated.

  2. Structure-based drug design projects focusing on glycosomal proteins from Trypanosoma brucei and Leishmania species. These are crystallographic studies in close collaboration with medicinal chemists, molecular modelers and parasitologists. The aims are (i) to improve the affinity of very promising inhibitors already developed in the course of the project, and (ii) to discover and design entirely novel inhibitors of other target proteins. Excellent expression systems of the target proteins are available. We are not only focusing in the active site and co-factor binding sites of enzymes but also on blocking glycosomal import signals of these glycosomal proteins.

  3. Crystallographic investigations on human and malaria topoisomerase I. Eukaryotic topoisomerases I are remarkable proteins able to relax both positively and negatively supercoiled DNA by breaking one strand of the duplex and resealing this broken strand after relaxing the DNA. Several structures have already been determined in our laboratory of human topoisomerase in complex with DNA. A major outstanding question is the way in which several inhibitors of topoisomerase I block the enzyme action. We not only wish to understand the mode of action of known topoisomerase inhibitors, but are also collaborating with synthetic chemists to develop novel inhibitors on the basis of our crystal structures, combined with molecular modeling and combinatorial chemistry approaches.

  4. Structural studies on components of members of the very large pyruvate dehydrogenase multi-enzyme complex family. These are wonderful, multi-million Dalton complexes with a highly symmetric core surrounded by a very dynamic and flexible arrangement of dozens of additional proteins. We are focusing on components of these complexes from human, Neisseria as well as other species.

The positions require a great interest in medically oriented protein crystallography and excellent crystallographic skills. Experience with protein expression and purification methods is also required for most projects. For some projects molecular biology know-how is beneficial, for others experience in protein-DNA interactions and for yet others knowledge of membrane protein crystallization would be a tremendous advantage.

Please address applications including the full addresses, fax and telephone numbers of three references to:

Wim G.J. Hol, Professor of Biological Structure and Biochemistry, HHMI investigator, Box 357742, University of Washington, Seattle WA 98195, USA
Fax: +1 206-685-7002 Email: [email protected]


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